Description
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💡 Let’s Start With Something Familiar
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You’ve probably felt it before:
You’re not eating more than usual — but fat still accumulates.
You sleep enough — but energy still feels off.
You’re not old — but your metabolism just doesn’t respond like it used to.
Most people blame themselves. But researchers point to something deeper:
the energy signaling happening inside your cells.
That’s exactly what AICAR was designed to investigate.
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🔬 What Is AICAR — In Plain English
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AICAR stands for 5-Aminoimidazole-4-carboxamide Ribonucleoside.
Long name. Simple concept.
Inside every cell, there’s a protein called AMPK — think of it as the cell’s internal energy manager. It monitors fuel levels and decides:
➜ Should we burn fat right now?
➜ Should we pull in more glucose?
➜ Should the mitochondria speed up?
When you exercise, your body naturally triggers AMPK because energy demand spikes. AICAR mimics that signal — without the treadmill.
Here’s how it works: once AICAR enters a cell, it converts into a compound called ZMP. ZMP acts like a low-energy alarm, telling AMPK to activate immediately — switching the cell into high-efficiency fuel mode.
That’s why researchers nicknamed it “exercise in a molecule.”
Not hype. Mechanism.
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📊 What the Research Actually Shows
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This isn’t a concept. These are conclusions from published studies:
🔥 Fat Metabolism
Research suggests AICAR may reduce the activity of SREBP-1c — a key regulator of fat production in liver cells — potentially decreasing fat accumulation while simultaneously supporting fatty acid oxidation. In simple terms: cells studied with AICAR appeared more likely to burn fat than store it.
⚡ Mitochondrial Energy
Multiple studies indicate that AMPK activation via AICAR supports mitochondrial biogenesis — meaning cells may develop more mitochondria and run more efficiently. This mirrors the kind of metabolic adaptation seen with consistent aerobic exercise training.
🩸 Glucose Regulation
In insulin-resistant animal models, AICAR was observed to increase glucose uptake in skeletal muscle cells while reducing hepatic glucose output. Researchers noted improvements in glucose homeostasis even at low doses, without significant changes in body weight.
❤️ Cellular Protection
In ischemia-related research (conditions where blood flow is restricted), AICAR demonstrated protective effects on cardiac cells — potentially by enhancing glucose availability at the cellular level under low-oxygen conditions, supporting cell survival under stress.
🧠 Inflammation Modulation
Several animal models showed AICAR’s ability to suppress NF-κB signaling in macrophages — one of the central pathways driving chronic inflammation. Reduced inflammatory markers were observed across models studying colitis, liver stress, and vascular health.
🧬 Tissue Repair Research
Studies examining fibroblast behavior suggest AICAR may support collagen production and extracellular matrix organization through AMPK-related pathways — pointing toward potential applications in wound healing and tissue regeneration research.
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🎯 Who Uses AICAR in Research — and Why
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AICAR has become a standard investigative tool used globally by:
✔ Metabolic disease research labs studying obesity and type 2 diabetes
✔ Exercise physiology teams exploring endurance and muscle adaptation
✔ Cardiovascular researchers investigating ischemia and vascular health
✔ Anti-aging and longevity science programs
✔ Inflammation and immunology research teams
Its value comes from one thing: consistency.
Across dozens of cell types and model systems, AICAR reliably activates AMPK — giving researchers a reproducible tool to study what happens when the energy switch turns on.
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📦 Product Specifications & Research Reference Data
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| Parameter | Detail |
|———–|——–|
| Chemical Name | 5-Aminoimidazole-4-carboxamide Ribonucleoside |
| Also Known As | Acadesine / AICA Ribonucleoside |
| CAS Number | 2627-69-2 |
| Molecular Weight | 258.23 g/mol |
| Appearance | White Lyophilized Powder |
| Purity | ≥98% (HPLC Verified) |
| Solubility | Water-soluble; reconstitute with sterile water or PBS |
| Storage | −20°C, dry and light-protected; 24-month shelf life (lyophilized) |
| In Vitro Reference Range | 0.5–2.0 mM concentration; 1–4 hour treatment window (per published literature) |
| Certificate of Analysis | Included with every order |
Available Sizes: 50mg / 100mg / 500mg / 1g
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✅ Why Researchers Choose Our AICAR
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✔ ≥98% purity — HPLC verified with full third-party CoA transparency
✔ Vacuum-sealed, light-protected packaging to preserve stability in transit
✔ Multiple size options — flexible for both small-scale and bulk research needs
✔ Every batch traceable — no guesswork on what you’re working with
✔ All product claims sourced from peer-reviewed, published scientific literature
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⚠️ Important Notice
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This product is a research-grade compound intended strictly for use by qualified researchers and licensed laboratory professionals. All content on this page is based on findings from published preclinical and in vitro studies and does not constitute medical advice, diagnosis, or treatment claims. AICAR is not approved by the FDA for human consumption or therapeutic use. Not for personal use or resale for human consumption.
